GPC1 Antibody, Biotin conjugated

Size : 50 µg Clone Number: Aliases: FLJ38078 antibody; glypican antibody; Glypican proteoglycan 1 antibody; glypican1 antibody; GPC 1 antibody; Gpc1 antibody; GPC1_HUMAN antibody; Secreted glypican-1 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P35052 Immunogen: Recombinant Human Glypican-1 protein (342-530AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA Background: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Biotin Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: GPC1 Research Areas: Neuroscience; Cancer; Signal transduction