GNA12 Antibody, FITC conjugated

Size : 50 µg Clone Number: Aliases: G alpha 12 antibody; G alpha-12 antibody; G-protein subunit alpha-12 antibody; gep antibody; Gna12 antibody; GNA12_HUMAN antibody; guanine nucleotide binding protein (G protein) alpha 12 antibody; Guanine nucleotide binding protein alpha 12 subunit antibody; Guanine nucleotide-binding protein subunit alpha-12 antibody; MGC104623 antibody; MGC99644 antibody; NNX3 antibody; RMP antibody; WUGSC: H_GS165O14.2 antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: Q03113 Immunogen: Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA) Host: Rabbit Reactivity: Human Tested Applications: Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed: 22609986, PubMed: 15525651, PubMed: 15240885, PubMed: 17565996, PubMed: 12515866, PubMed: 16787920, PubMed: 16705036, PubMed: 23762476, PubMed: 27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed: 15240885, PubMed: 12515866, PubMed: 16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed: 15525651, PubMed: 17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed: 23762476, PubMed: 16787920, PubMed: 16705036, PubMed: 27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed: 11976333, PubMed: 16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed: 15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed: 22609986). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: FITC Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: GNA12 Research Areas: Signal transduction