GLRB Antibody

Size : 50 µg Clone Number: Aliases: GLRBGlycine receptor subunit beta antibody; Glycine receptor 58 kDa subunit antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P48167 Immunogen: Recombinant Human Glycine receptor subunit beta protein (355-472AA) Host: Rabbit Reactivity: Human Tested Applications: ELISA, IF; Recommended dilution: IF: 1: 200-1: 500 Background: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed: 8717357, PubMed: 15302677, PubMed: 16144831, PubMed: 22715885, PubMed: 25445488, PubMed: 11929858, PubMed: 23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed: 8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed: 11929858, PubMed: 23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed: 25445488). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: Non-conjugated Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: GLRB Research Areas: Neuroscience; Signal transduction