GLRA1 Antibody, FITC conjugated

Size : 50 µg Clone Number: Aliases: GLRA1 antibody; GLRA1_HUMAN antibody; Glycine receptor 48 kDa subunit antibody; Glycine receptor alpha 1 antibody; Glycine receptor strychnine-binding subunit antibody; Glycine receptor subunit alpha-1 antibody; Glycine receptor; alpha 1 subunit antibody; HKPX1 antibody; STHE antibody Product Type: Polyclonal Antibody Immunogen Species: Homo sapiens (Human) UniProt ID: P23415 Immunogen: Recombinant Human Glycine receptor subunit alpha-1 protein (23-113AA) Host: Rabbit Reactivity: Human Tested Applications: Background: Glycine receptors are ligand-gated chloride channels (PubMed: 23994010, PubMed: 25730860). Channel opening is triggered by extracellular glycine (PubMed: 2155780, PubMed: 7920629, PubMed: 14551753, PubMed: 16144831, PubMed: 22715885, PubMed: 22973015, PubMed: 25973519, PubMed: 9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed: 16144831, PubMed: 9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed: 14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed: 8298642, PubMed: 9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed: 25445488). Channel activity is potentiated by ethanol (PubMed: 25973519). Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity). Clonality: Polyclonal Isotype: IgG Purification Method: 95%, Protein G purified Conjugate: FITC Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: GLRA1 Research Areas: Neuroscience