📈 Why Single-Cell Multiomics Matters

Traditional "bulk" sequencing masks cellular heterogeneity by averaging signals across millions of cells. Single-cell multiomics enables researchers to:

• Capture the true diversity of cell states
• Discover rare cell populations (e.g., stem-like cancer cells)
• Understand how genomic, transcriptomic, and epigenetic programs interact
• Build cell atlases for organs and diseases

"Every cell tells a story. Multiomics lets us read every chapter."

📊 Key Modalities in Single-Cell Multiomics

 scRNA-seq: Single-Cell Transcriptomics

• Measures gene expression in thousands to millions of individual cells.
• Useful for identifying cell types, cell states, and developmental trajectories.

scATAC-seq: Chromatin Accessibility

• Reveals which parts of the genome are open and active in each cell.
• Helps in linking enhancers to target genes and understanding epigenetic regulation.

 CITE-seq: Protein + RNA Quantification

• Uses oligo-tagged antibodies to quantify surface proteins and RNA in parallel.
• Bridges the gap between transcriptome and proteome.

Multiome-seq / SNARE-seq

• Captures both RNA and chromatin accessibility from the same cell.
• Enables integrative models of gene regulation.

Spatial Transcriptomics (Optional Integration)

• Localizes gene expression within tissue architecture.
• Can be integrated with scRNA-seq for spatial context.

🌍 Applications Across the Biomedical Landscape

 Cancer Research

• Identifying tumor subclones
• Understanding therapy resistance
• Mapping tumor-immune microenvironments

Developmental Biology

• Tracing lineage trajectories
• Mapping differentiation in embryos
• Studying tissue morphogenesis

 Immunology

• Profiling immune responses to infection or vaccination
• Understanding autoimmune disease at the cellular level
• Defining T-cell receptor and B-cell receptor diversity

Neuroscience

• Deconstructing brain cell types and regional variation
• Linking gene expression to function in health and disease
• Studying neurodevelopmental and neurodegenerative disorders